Tonalin Conjugated Linoleic Acid (CLA) Many Uses Page

The Power of Tonalin CLA

Studies show that CLA (the active ingredient in Tonalin® CLA) works three ways to help you achieve your diet goals.
CLA (Conjugated Linoleic Acid) by Tonalin, the only CLA supplement clinically tested for weight loss.
CLA interferes with a substance in your body called lipoprotein lipase that helps store fat in your body.

CLA helps your body use its existing fat for energy.

CLA increases lean muscle tissue, which naturally slims your body (and makes you feel strong and healthy). And the more muscle you have, the more calories your body uses in order to function, thereby speeding up the fat burning process.
As a result, you get smaller in all the right places. You drop clothes sizes. You look great. You feel great. And no yo-yo dieting effect.

Dietary CLA has been shown to effect body composition by creating a reduction in body fat and an enhancement of lean tissue or muscle. According to Michael Pariza at the University of Wisconsin, this area of CLA research is the most supported. Recently, the research has focused on
clinical studies with much success; showing statistically significant reduction in body fat as measured by BMI (Body Mass Index). A significant decrease measured in waistline measured in inches, a positive result for weight loss in mildly overweight subjects and an increase in strength. Human clinical studies to substantiate improved body composition have been conducted worldwide. Positive results of CLA supplementation have been seen at research centers worldwide.

Kent State University, University of Memphis, University of Wisconsin, USDA Western Human Research Center, Medstat Research Ltd. in Norway, Uppsala University in Sweden, University of Kumanoto in Japan and University of Tours in France.

CLA appears to exert direct effects on adipocytes, which are the principle sites of fat storage and skeletal muscle cells and are the primary sites of fat combustion. It has been proposed that the physiologic mechanism of body fat reduction by CLA involves inhibition of fat storage in adipocytes coupled with elevated b-oxidation in skeletal muscle. An overall increase in skeletal muscle tissue may be mediated at least in part via the inhibition of immune-induced catabolism.

CLA is a metabolically active compound that has been demonstrated to dramatically reduce body fat and increase lean body tissue. The mechanisms of action are not completely understood, but because CLA has been shown to affect a wide variety of enzymes and hormones in the body, multiple mechanisms may come into play. Numerous human studies are in progress, which will make a stronger case for efficacy and dose response. Expectations are high that research will additionally show no regain of body fat lost, suggesting that Tonalin™ CLA should be included with every diet regimen.

Tonalin® CLA is best known for helping to reduce body fat and increase lean muscle tissue.
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Beyond Diet Goals

Not only does Tonalin® have no harmful side effects, but it's actually good for your body. As a matter of fact, scientists worldwide are just begining to understand CLA's wide range of potential health benefits. Here are quick summaries of CLA's current four principal health benefit areas.

Not only does Tonalin® have no harmful side effects, but it's actually good for your body.
Tonalin vs. Cancer
In the early 1980s, a noted doctor, Michael Pariza, working at the University of Wisconsin and his colleagues discovered that CLA interfered with the growth of cancer tumors.

Since then, a number of other studies have further shown CLA's cancer-fighting potential. Some of these studies have shown that CLA can suppress cancer development in animals, and in human cancer cell lines in vitro.

Dietary CLA also seems to protective against breast cancer in humans, as demonstrated in a large French study by Lavillonniere et. al. at the University Francois-Rabelais. When breast adipose tissue was collected at the time of surgery, higher levels of CLA in the control group suggested CLA's protective effect against breast cancer. A different study in Finland confirmed the reverse correlation between milkfat intake, which contains CLA and breast cancer.

Over the next few years, additional studies are planned to help further understand the role CLA may play in the fight against cancer.

Over time, cholesterol and other substances can form plaque in your arteries, narrowing them, reducing your heart's blood supply. This is artherosclerosis, and it can kill you.

In a collaborative study where a diet high in cholesterol was fed along with CLA to animals, the data suggested that CLA could help prevent artherosclerosis. By week 12, the LDL and total cholesterol and triglyceride counts were markedly lower in the blood of the animals fed CLA.

Other studies have indicated that CLA reduces plasma lipoproteins and early aortic atherosclerosis in the animal model. According to Dr. David Kritchevsky at the Wistar Institute, another significant finding is the apparent ability of CLA to reduce the severity of preinduced atherosclerosis lesions in the animal model.

Overall, CLA has considerable potential for the prevention and treatment of artherosclerosis, and studies continue to reveal it's potential health benefits.

One of the most important health benefits of CLA could possibly be its ability to affect and treat some types of diabetes. According to Dr. Martha Belury at Purdue University and Dr. John Vandel Heuvel at Penn State University, CLA normalizes impaired glucose tolerance in non insulin-dependent diabetes. In earlier experiments by Houseknecht et. al., it was observed that CLA and troglitazone reversed the symptoms of diabetes in a specific diabetic animal model. Effects included decreased triglycerides, insulin and leptin, and improved glucose utilization. Belury and Vanden Heuvel conclude that CLA may represent an important agent for the treatment of Type II diabetes.

Because CLA isomers share many of the attributes of the clinical thiazolidinedione drug, troglitazone, without exhibiting as many side effects, CLA may represent a new insulin-sensitizing agent for treatment of Type II diabetes.

Additional clinical studies are scheduled at many universities worldwide in order to further explore the possibilities of using CLA for diabetes treatment.

In 1991, evidence obtained through the collaborative efforts of Dr. Mark Cook and Dr. Michael Pariza at the University of Wisconsin revealed the immune boosting potential of CLA. Feeding CLA to chicks provided partial protection against the catabolic effects of exposure to endotoxin. This research expanded to include rodents and supported the fact that CLA-fed animals exhibit enhanced immune functions.

CLA is the only known nutrient that enhances the immune system and protects against the harmful "cellular backlash" that occurs when the immune system is stimulated.

As published in sperate issues of Cancer Research, CLA has been shown to be an effective antioxidant in vitro according to Dr. Yeong Ha and in vivo according to Dr. Clement Ip. Because numerous studies indicate that oxidative reactions are associated with the development of cancer and atherosclerosis, CLA's ability to reduce the harmful effects of these oxidative reactions could be its most important health benefit

In addition, research suggests that CLA may ease the inflammation that occurs when the immune system is challenged.

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